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Glimepiride, a sulfonylurea, lowers blood glucose by stimulating insulin release from functioning pancreatic beta cells. It improves beta-cell sensitivity to glucose and has additional effects, such as:
- Reducing hepatic glucose production.
- Increasing peripheral tissue sensitivity to insulin.
- Enhancing glucose uptake.
The blood sugar-lowering effect of a single Glimirid dose can last 24 hours in non-fasting diabetic patients.
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✅ Description:
Glimirid Tablet is used for:
- Lowering blood glucose in patients with non-insulin-dependent diabetes mellitus (Type II diabetes) when diet and exercise alone are insufficient.
- Combination therapy with metformin when monotherapy with Glimirid or metformin alone does not provide adequate blood sugar control.
- Combination therapy with insulin when oral hypoglycemic agents, diet, and exercise do not effectively control blood sugar levels.
Note: Combining Glimirid with insulin may increase the risk of hypoglycemia.
Always take this medication as prescribed by a registered physician.
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✔️ Dosage & Administration:
Dosage depends on individual blood sugar levels. The lowest effective dose should be used. Blood and urine glucose levels should be monitored regularly to adjust the dosage.
Initial Dose & Titration:
- Start with 1 mg once daily.
- If necessary, increase gradually at 1-2 week intervals as follows:
1 mg → 2 mg → 3 mg → 4 mg → 6 mg.
Maintenance Dose:
- Most patients with well-controlled diabetes require 1-4 mg daily.
Dose Timing:
- Usually taken once daily before a substantial breakfast or the first main meal.
- Skipping meals after taking Glimirid may lead to hypoglycemia.
Secondary Dosage Adjustment:
- As diabetes control improves, insulin sensitivity increases, and the dose of Glimirid may need to be reduced to prevent hypoglycemia.
- Dose adjustments are needed with changes in weight, lifestyle, or other factors affecting blood sugar levels.
Switching from Other Oral Antidiabetics to Glimirid:
- Initial dose: 1 mg daily, regardless of previous medication dose.
- Gradual dose increase based on blood sugar levels.
- A gap between switching medications may be required to avoid hypoglycemia.
Take Glimirid tablets with sufficient liquid.
✔️ Side Effects:
- Common: Hypoglycemia, temporary vision disturbances, nausea, vomiting, diarrhea, abdominal pain, low blood pressure, skin reactions (urticaria).
✔️ Drug Interactions:
Medications that may increase the effect of Glimirid (leading to hypoglycemia):
- Insulin & other antidiabetics
- ACE inhibitors
- Sulfonamide antibiotics
- Fluconazole, fluoxetine
- Beta-blockers
- MAO inhibitors
- Salicylates (e.g., aspirin)
✔️ Medications that may reduce the effect of Glimirid (leading to high blood sugar):
- Corticosteroids
- Diuretics
- Thyroid hormones
- Phenothiazines
- Barbiturates
✔️ Glimirid must not be used in:
- Type 1 diabetes mellitus.
- Diabetic ketoacidosis or diabetic coma.
- Patients allergic to sulfonylureas, sulfonamides, or Glimirid.
- Severe liver or kidney dysfunction.
✔️ Overdose Effects:
- Mild Hypoglycemia: Treat with oral glucose and adjust medication/meal intake.
- Severe Hypoglycemia (coma, seizures):
- Emergency hospitalization required.
- IV glucose (50%) should be administered immediately, followed by continuous IV glucose (10%) to maintain blood sugar levels above 100 mg/dL.
- Monitor for 24-48 hours, as hypoglycemia may recur.
✔️ Pregnancy & Lactation:
- Not recommended during pregnancy; insulin should be used instead.
- Breastfeeding is contraindicated, as Glimirid can pass into breast milk and harm the infant.
✔️ Precautions & Warnings:
- Risk of hypoglycemia is higher in the first weeks of treatment.
- Hypoglycemia can be managed with glucose or sugar intake.
- Adjust dose if lifestyle, weight, or health conditions change.
✔️ Storage:
- Store below 30°C, away from light and moisture.
- Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
